Article

Pharmacological recruitment of a VTA glutamatergic arousal circuit by the natural product BN3 drives broad-spectrum emergence from general anesthesia

2026-02-18

Abstract excerpt

Pharmacological control of emergence from general anesthesia remains strikingly limited. Clinically available antagonists are largely drug-class specific, leaving recovery dependent on anesthetic clearance rather than to an actively programmable switch in brain state. Through phenotypic screening of a structurally diverse natural-product library, we identified BN3 (L-(−)-camphor) as a broad-spectrum emergence agen...

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Literature Corpus work: 465f0f00-96ff-570a-84ea-950aa888c50c
DOI: 10.64898/2026.02.17.706054

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Pharmacological recruitment of a VTA glutamatergic arousal circuit by the natural product BN3 drives broad-spectrum emergence from general anesthesiaDOI 10.64898/2026.02.17.706054Read

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