Article

Elp1 is required for development of visceral sensory peripheral and central circuitry

2022-04-11

Abstract excerpt

Cardiovascular instability and a blunted respiratory drive in hypoxic conditions, are hallmark features of the genetic sensory and autonomic neuropathy, familial dysautonomia (FD). FD results from a mutation in the gene ELP1 , whose encoded protein is a scaffolding subunit of the six subunit Elongator complex. In mice, we and others have shown that Elp1 is essential for the normal development of neural crest der...

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Literature Corpus work: c219c182-9cd3-5a62-9f74-a3c85c8b9f67
DOI: 10.1101/2022.04.11.487663

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