Article

A Rare Case of Recurrent Ovarian Cancer With NTRK1-TPM3 Gene Rearrangement

2021-09-16

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> <italic>NTRK</italic> gene fusion is rare in gynecologic cancer. Entrectinib is a novel targeted drug which is a potent inhibitor of TRK A, B and C. Here, we present a case of recurrent ovarian cancer with <italic>NTRK1-TPM3</italic> rearrangement, which was detected by next-generation sequencing (NGS) and treated with entrectinib. <bold>Case Presentation: </bol...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c1b30420-9f60-5d31-b45f-47114b5ba9c9
DOI: 10.21203/rs.3.rs-739649/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Rare Case of Recurrent Ovarian Cancer With NTRK1-TPM3 Gene RearrangementDOI 10.21203/rs.3.rs-739649/v2Read

TRKing down an old oncogene in a new era of targeted therapy.Semantic proximity Read

Expert consensus on the diagnosis and treatment of NTRK gene fusion solid tumors in ChinaSemantic proximity Read

Landscape of potentially targetable receptor tyrosine kinase fusions in diverse cancers by DNA-based profilingSemantic proximity Read

China special issue on gastrointestinal tumors-NTRK fusion in a large real-world population and clinical utility of circulating tumor DNA genotyping to guide TRK inhibitor treatment.Semantic proximity Read

A review of NTRK fusions in cancerSemantic proximity Read

Clinicopathologic and molecular spectrum of gastrointestinal stromal tumor (GIST) with NTRK fusion and marked response to Larotrectinib in GIST with NTRK fusion: a case reportSemantic proximity Read

[Diagnosis and therapy of tumors with NTRK gene fusion].Semantic proximity Read

TRK Inhibition: A New Tumor-Agnostic Treatment StrategySemantic proximity Read

Next‐generation sequencing unravels extensive genetic alteration in recurrent ovarian cancer and unique genetic changes in drug‐resistant recurrent ovarian cancerSemantic proximity Read

Investigating the Natural History and Prognostic Nature of NTRK Gene Fusions in Solid TumorsSemantic proximity Read

NTRK-Rearranged Spindle Cell Tumor with SPECC1L-NTRK3 Fusion in the Thoracic Spine: A Case ReportSemantic proximity Read

NTRK1-3 Fusions in Sarcomas: Prevalence, Significance, and Clinical Implications – A Systematic ReviewSemantic proximity Read