Article

Restoration of visual function by transplantation of optogenetically engineered photoreceptors

2018-08-25

Abstract excerpt

A major challenge in the treatment of retinal degenerative diseases, with the transplantation of replacement photoreceptors, is the difficulty in inducing the grafted cells to grow and maintain light sensitive outer segments (OS) in the host retina, which depends on proper interaction with the underlying retinal pigment epithelium (RPE). For a RPE-independent treatment approach, we introduced a hyperpolarizing mic...

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Literature Corpus work: 72960fbd-45a3-5001-a018-c526893324b3
DOI: 10.1101/399725

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