Article

Pre-symptomatic reduction of individuality in the App <sup>NL-F</sup> knock-in model of Alzheimer’s disease

2022-08-21

Abstract excerpt

While one third of the risk for Alzheimer’s disease (AD) is explained by environment and lifestyle, AD pathology also affects individual lifestyle, possibly long before clinical manifestation of dementia. To study this hidden disease effect with its potentially large impact on coping with AD, we examined in mice how the App NL-F/NL-F (NL-F) knock-in mutation affects the pre-symptomatic response to environmental e...

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Literature Corpus work: c1b18ca4-6102-5535-a9de-5f6ee1f8ff81
DOI: 10.1101/2022.08.18.504396

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