KDM5B drives acute liver injury by impairing autophagy and activating cGAS-STING signaling via binding to ATG16L1

Abstract excerpt

<title>Abstract</title> <p>Acute liver injury (ALI) is a severe hepatic disorder characterized by high morbidity and mortality, presenting major challenges for clinical management. However, its underlying pathogenesis remains incompletely understood. Through analysis of four Gene Expression Omnibus (GEO) datasets using the Robust Rank Aggregation (RRA) method and RNA sequencing, the histone demethylase KDM5B was...

Topics

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• Advanced Glycation End Products research
• Cancer-related molecular mechanisms research
• Hepatitis B Virus Studies
• Immune Response and Inflammation
• interferon and immune responses
• NF-κB Signaling Pathways
• RNA modifications and cancer
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

c1aef3ff-045c-50e9-8647-25e2b049a23b

DOI

10.21203/rs.3.rs-7430149/v1