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Article

An In-Depth Evaluation of the Validity and Logistics Surrounding the Testing of AR-V7 mRNA Expression in Circulating Tumor Cells.

The Journal of molecular diagnostics : JMD - 1 May 2018

Sieuwerts Anieta M, Mostert Bianca, van der Vlugt-Daane Michelle, Kraan Jaco, Beaufort Corine M, Van Mai, Prager Wendy J C, De Laere Bram, Beije Nick, Hamberg Paul, Westgeest Hans M, Tascilar Metin, Dirix Luc Y, Onstenk Wendy, de Wit Ronald, Lolkema Martijn P, Mathijssen Ron H J, Martens John W M, Sleijfer Stefan

Abstract excerpt

Recent reports have emphasized the clinical relevance of detecting AR-V7 in circulating tumor cells (CTCs). Our aim was to set up a validated multicenter pipeline to measure AR-V7 by quantitative RT-PCR (RT-qPCR) in RNA isolated from CellSearch-enriched CTCs to provide an AR-V7-positive or AR-V7-negative score in a clinically acceptable time range. CellSearch-enirched CTCs from patients with metastatic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29474983
DOI: 10.1016/j.jmoldx.2018.01.008

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