Article

A hypothalamus-liver-skeletal muscle axis controlled by JNK1 and FGF21 mediates olanzapine-induced insulin resistance in an intraperitoneal treatment in male mice

2026-01-12

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Olanzapine (OLA), a widely prescribed second-generation antipsychotic, is associated with adverse metabolic effects. We recently showed that oral OLA treatment in male mice induces weight gain and hepatic steatosis, whereas intraperitoneal (i.p.) administration leads to weight loss due to higher hypothalamic OLA levels and activation of brown adipose tissue. Since clinical s...

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Literature Corpus work: c1a0ec49-eef1-5671-8bf3-b9ce4cb0031b
DOI: 10.64898/2026.01.12.698937

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