Article

Intestinal helminth infection impairs vaccine-induced T cell responses and protection against SARS-CoV-2

2024-01-15

Abstract excerpt

<h4>SUMMARY</h4> Although vaccines have reduced COVID-19 disease burden, their efficacy in helminth infection endemic areas is not well characterized. We evaluated the impact of infection by Heligmosomoides polygyrus bakeri (Hpb), a murine intestinal hookworm, on the efficacy of an mRNA vaccine targeting the Wuhan-1 spike protein of SARS-CoV-2. Although immunization generated similar B cell responses in Hpb-infe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9fce99f9-bbdf-573d-9fc3-eebeaeb539ee
DOI: 10.1101/2024.01.14.575588

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Intestinal helminth infection impairs vaccine-induced T cell responses and protection against SARS-CoV-2DOI 10.1101/2024.01.14.575588Read

Robust COVID-19 Vaccine Responses Despite Filarial Co-Infection: Insights from a Lymphatic Filariasis Cohort in GhanaSemantic proximity Read

Strain- and vaccine-specific effects of serum antibodies in the protection of intestinal SARS-CoV-2 infectionSemantic proximity Read

A single dose, BCG-adjuvanted COVID-19 vaccine provides sterilizing immunity against SARS-CoV-2 infection in miceSemantic proximity Read

COVID-19 Lethality in Sub-Saharan Africa and Helminth Immune ModulationSemantic proximity Read

Multi-omic Profiling, Structural Characterization and Potent Inhibitor Screening of Evasion Related Proteins of a Parasitic Nematode, Haemonchus contortus, Surviving Vaccine TreatmentSemantic proximity Read

Helminths' antigens differentially modulate the activation of SARS-CoV-2-reactive helper and cytotoxic T cells in COVID-19 patients and healthy blood donors.Semantic proximity Read

Helminth infection is linked to an impaired neutralisation response to SARS-CoV-2 post vaccinationSemantic proximity Read

Human challenge study with a Shigella bioconjugate vaccine: Analyses of clinical efficacy and correlate of protectionSemantic proximity Read

mRNA vaccines encoding variant forms of Sm-TSP-2 confer protective immunity against Schistosoma mansoniSemantic proximity Read

Environmental drivers of low vaccine responsiveness in a lab-to-wild rodent modelSemantic proximity Read

Heterogeneous Tfh cell populations that develop during enteric helminth infection predict the quality of type 2 protective responseSemantic proximity Read

Immune modulation and modulators in Heligmosomoides polygyrus infection.Semantic proximity Read