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Article

Structural and Functional Characterization of Schistosoma mansoni Cathepsin B1.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020

Jílková Adéla, Horn Martin, Mareš Michael

Abstract excerpt

Schistosomiasis caused by parasitic blood flukes of the genus Schistosoma is a global health problem with over 200 million people infected. Schistosoma mansoni cathepsin B1 (SmCB1) is a gut-associated protease critical for digestion of host blood proteins as a source of nutrients. SmCB1 is a validated drug target, and inhibitors of SmCB1 represent promising anti-schistosomals. A comprehensive structural and...

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PMID: 32452002
DOI: 10.1007/978-1-0716-0635-3_12

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