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IFN-γ Priming Up-Regulates IFN-Stimulated Gene Factor 3 (ISGF3) Components, Augmenting Responsiveness of IFN-Resistant Melanoma Cells to Type I IFNs

1998-06-01

Abstract excerpt

Abstract IFN-stimulated gene factor 3 (ISGF3) mediates transcriptional activation of IFN-sensitive genes (ISGs). The component subunits of ISGF3, STAT1αβ, STAT2, and p48-ISGF3γ, are tyrosine phosphorylated before their assembly into a complex. Subsequently, the ISGF3 complex is translocated to the nucleus. We have recently established that the responsiveness of human melanoma cell lines to type I IFNs correlates d...

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Literature Corpus work
c1218d7d-5d23-54eb-beaa-4c5917ea869f
DOI
10.4049/jimmunol.160.11.5475
Open publication

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IFN-γ Priming Up-Regulates IFN-Stimulated Gene Factor 3 (ISGF3) Components, Augmenting Responsiveness of IFN-Resistant Melanoma Cells to Type I IFNsDOI 10.4049/jimmunol.160.11.5475
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