Article

Risk of differential cancer types over age in families with Li-Fraumeni syndrome: a validation study using multi-center cohorts

2019-03-05

Abstract excerpt

<h4>ABSTRACT</h4> Li-Fraumeni syndrome (LFS) is a rare hereditary cancer syndrome associated with an autosomal dominant mutation inheritance in the TP53 tumor suppressor gene and a wide spectrum of cancer diagnoses. An accurate estimation of the penetrance of different cancer types in LFS is crucial to improve the clinical characterization and management of high-risk individuals of LFS. Our competing risk-based...

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Literature Corpus work: c1160a6b-c92f-5d9c-b6f7-e60bfcbadaef
DOI: 10.1101/567727

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