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Article

Penetrance Estimates Over Time to First and Second Primary Cancer Diagnosis in Families with Li-Fraumeni Syndrome: A Single Institution Perspective.

Cancer research - 15 Jan 2020

Shin Seung Jun, Dodd-Eaton Elissa B, Gao Fan, Bojadzieva Jasmina, Chen Jingxiao, Kong Xianhua, Amos Christopher I, Ning Jing, Strong Louise C, Wang Wenyi

Abstract excerpt

Li-Fraumeni syndrome (LFS) is a rare autosomal dominant disorder associated with TP53 germline mutations and an increased lifetime risk of multiple primary cancers (MPC). Penetrance estimation of time to first and second primary cancer within LFS remains challenging because of limited data and the difficulty of characterizing the effects of a primary cancer on the penetrance of a second primary cancer. Using a...

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Identifiers

PMID: 31719099
DOI: 10.1158/0008-5472.CAN-19-0725
PMCID: PMC6980737

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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