Article

CorrAdjust unveils biologically relevant transcriptomic correlations by efficiently eliminating hidden confounders

2024-12-25

Abstract excerpt

Correcting for confounding variables is often overlooked when computing RNA-RNA correlations, even though it can profoundly affect results. We introduce CorrAdjust, a method for identifying and correcting such hidden confounders. CorrAdjust selects a subset of principal components to residualize from expression data by maximizing the enrichment of “reference pairs” among highly correlated RNA-RNA pairs. Unlike tra...

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Literature Corpus work: c0c80a58-cd30-5403-9a98-c9208fc6edff
DOI: 10.1101/2024.12.24.630258

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