Article

When batch correction corrupts gene expression: uncovering distortions in correlation structures

2026-06-10

Abstract excerpt

Batch correction is essential for integrating datasets and enabling population-level insights into health and disease. Embedding-based approaches are among the most widely used solutions, but here we highlight a critical, overlooked limitation: these methods can distort feature-to-feature (e.g., gene–gene) relationships, potentially undermining downstream analyses. We investigate this issue and introduce a novel m...

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Literature Corpus work: c2ebeccf-4316-5eb4-b1e5-fc00e5a143d8
DOI: 10.64898/2026.06.06.729466

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