Article

Simple models including energy and spike constraints reproduce complex activity patterns and metabolic disruptions

2020-02-19

Abstract excerpt

In this work, we introduce new phenomenological neuronal models ( e LIF and mAdExp) that account for energy supply and demand in the cell as well as the inactivation of spike generation how these interact with subthreshold and spiking dynamics. Including these constraints, the new models reproduce a broad range of biologically-relevant behaviors that are identified to be crucial in many neurological disorders, bu...

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Literature Corpus work: 4654acbe-f4e0-51ae-87cb-c43a7dec96b8
DOI: 10.1101/2020.02.19.955898

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