Article

High-throughput identification of FLT3 wild-type and mutant kinase substrate preferences and application to design of sensitive <i>in vitro</i> kinase assay substrates

2018-10-31

Abstract excerpt

<h4>Summary</h4> Acute myeloid leukemia (AML) is an aggressive disease that is characterized by abnormal increase of immature myeloblasts in blood and bone marrow. The FLT3 receptor tyrosine kinase plays an integral role in haematopoiesis, and one third of AML diagnoses exhibit gain-of-function mutations in FLT3, with the juxtamembrane domain internal tandem duplication (ITD) and the kinase domain D835Y variants...

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Literature Corpus work: c045c907-5c37-5a7d-8720-712b18e1f17b
DOI: 10.1101/457689

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