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Article

Generation and characterization of a highly effective protein substrate for analysis of FLT3 activity.

Journal of hematology & oncology - 16 Jul 2012

Chen Yun, Guo Yao, Han Jiayu, Ho Wanting Tina, Li Shibo, Fu Xueqi, Zhao Zhizhuang Joe

Abstract excerpt

BACKGROUND: Gain-of-function mutations of tyrosine kinase FLT3 are frequently found in acute myeloid leukemia (AML). This has made FLT3 an important marker for disease diagnosis and a highly attractive target for therapeutic drug development. This study is intended to generate a sensitive substra...

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Source

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Identifiers

PMID: 22800464
DOI: 10.1186/1756-8722-5-39
PMCID: PMC3419602

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22800464-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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