Article

Chromosomal Aberration of the 11q23 Locus in Acute Leukemia and Frequency ofMLLGene Translocation

2004-08-01

Abstract excerpt

Structural abnormality of the 11q23 band (11q23+) bearing the MLL gene translocation (MLL+) is a recurrent chromosome change observed in 3% to 7% of acute lymphoblastic leukemias and in 3% to 4% of acute myeloblastic leukemias. The resolution of conventional cytogenetics (CC) in detecting 11q23 rearrangement is limited when the translocative partner has a telomeric location; furthermore, CC can barely discriminate...

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Literature Corpus work: bec5b080-1bf4-582d-b33c-165c51d31bdc
DOI: 10.1309/rx27r8gjqm330c22

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