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Article

Rearrangement of the MLL Gene in Acute Lymphoblastic and Acute Myeloid Leukemias with 11q23 Chromosomal Translocations

23 Sept 1993

Abstract excerpt

BACKGROUND: Translocations involving chromosome band 11q23 are very frequent in both acute lymphoblastic and acute myeloid leukemias and are the most common genetic alteration in infants with leukemia. In all age groups and all phenotypes of leukemia, an 11q23 translocation carries a poor prognosis. A major question has been whether one or several genes on band 11q23 are implicated in these leukemias. Previously,...

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PMID: 8361504
DOI: 10.1056/nejm199309233291302

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Related research

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Click a neighbor to travelStep 1 · 12 closest

Rearrangement of the MLL Gene in Acute Lymphoblastic and Acute Myeloid Leukemias with 11q23 Chromosomal TranslocationsPMID 8361504Read ↗

Chromosomal Aberration of the 11q23 Locus in Acute Leukemia and Frequency of MLL Gene Translocation Results in 378 Adult PatientsSemantic proximity Read ↗

Comparison of cytogenetics, Southern blotting, and fluorescence in situ hybridization as methods for detecting MLL gene rearrangements in children with acute leukemia and with 11q23 abnormalities.Semantic proximity Read ↗

Chromosomal Aberration of the 11q23 Locus in Acute Leukemia and Frequency ofMLLGene TranslocationSemantic proximity Read ↗

Acute lymphoblastic leukemias with deletion of 11q23 or a novel inversion (11)(p13q23) lack MLL gene rearrangements and have favorable clinical featuresSemantic proximity Read ↗

Rearrangement of the MLL gene confers a poor prognosis in childhood acute lymphoblastic leukemia, regardless of presenting ageSemantic proximity Read ↗

Molecular rearrangements of the MLL gene are present in most cases of infant acute myeloid leukemia and are strongly correlated with monocytic or myelomonocytic phenotypes.Semantic proximity Read ↗

MLL Genomic Breakpoint Distribution Within the Breakpoint Cluster Region in De Novo Leukemia in ChildrenSemantic proximity Read ↗

Clinical and biological implications of partial tandem duplication of the MLL gene in acute myeloid leukemia without chromosomal abnormalities at 11q23.Semantic proximity Read ↗

Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcomeSemantic proximity Read ↗

Chromosomal Rearrangements Leading to MLL Gene Fusions: Clinical and Biological AspectsSemantic proximity Read ↗

Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcomeSemantic proximity Read ↗

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias.Semantic proximity Read ↗

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