Article

Lyophilized mRNA-lipid nanoparticle vaccines with long-term stability and high antigenicity against SARS-CoV-2

2022-02-10

Abstract excerpt

Advanced mRNA vaccines play vital roles against SARS-CoV-2. However, due to their poor stability, most current mRNA delivery platforms need to be stored at -20°C or -70°C, which severely limits their distribution. Herein, we present lyophilized SARS-CoV-2 mRNA-lipid nanoparticle vaccines, which can be stored at room temperature with long-term thermostability. In the in vivo Delta virus challenge experiment, lyoph...

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Literature Corpus work: 1cb9dc7f-731d-5db1-a084-49a4e9a8462e
DOI: 10.1101/2022.02.10.479867

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