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Carboxy‐terminal truncations of mouse α‐synuclein alter aggregation and prion‐like seeding

8 Jan 2020

Abstract excerpt

α-synuclein (αsyn) forms pathologic inclusions in several neurodegenerative diseases termed synucleinopathies. The inclusions are comprised of αsyn fibrils harboring prion-like properties. Prion-like activity of αsyn has been studied by intracerebral injection of fibrils into mice, where the presence of a species barrier requires the use of mouse αsyn. Post-translational modifications to αsyn such as carboxy...

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PMID: 31912891
DOI: 10.1002/1873-3468.13728

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