Article

Variable Selection for Generalized Single-index Varying-coefficient Models with Applications to Synergistic G×E Interactions

2025-01-03

Abstract excerpt

Complex diseases such as type 2 diabetes are influenced by both environmental and genetic risk factors, leading to a growing interest in identifying gene-environment (G×E) interactions. Guan et al. (2023) proposed a three-step variable selection method for single-index varying-coefficients models. This method selects varying and constant effect genetic predictors, as well as non-zero loading parameters, to identif...

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Literature Corpus work: be8010d6-22fa-5c83-b053-bbb77adbbef2
DOI: 10.20944/preprints202412.2644.v1

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