Article

Proteomic analysis of blood neuronal and glial extracellular vesicles reveals neuroprotective effects of the angiotensin type-1 blocker candesartan in Parkinson’s disease patients

2025-05-06

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The renin-angiotensin system (RAS) is a major regulator of cell homeostasis, oxidative stress, and inflammatory responses in different tissues, including the brain. In Parkinson’s disease (PD) models, activation of angiotensin type-1 receptors (AT1) increased the vulnerability of dopaminergic neurons, which was inhibited by AT1 blockers (ARBs). This is consistent with recent s...

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Literature Corpus work: 46d09bac-ff4b-5f46-aa0c-7194c8439739
DOI: 10.1101/2025.05.02.25326639

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