Article

Exosomes derived from human placental MSCs carrying miR-4450 inhibitor alleviate intervertebral disc degeneration and ameliorate gait disturbances via up-regulation of ZNF121

2020-05-15

Abstract excerpt

<title>Abstract</title> <p>Background Exosomes derived from mesenchymal stem cells (MSCs) have emerged as novel drug and gene delivery tools. Current study aimed to elucidate the potential therapeutic role of human placental MSC (hPLMSC)-derived exosomes carrying antagomiR-4450 (EXO-antagomiR-4450) in intervertebral disc degeneration (IDD) progression. Methods Initially, the differentially expressed miRNAs rela...

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Literature Corpus work: be3f9984-ce8a-56a5-9514-9f49f03acb58
DOI: 10.21203/rs.3.rs-28561/v1

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