Article

Consistent metagenome-derived metrics verify and define bacterial species boundaries

2019-05-24

Abstract excerpt

Longstanding questions relate to the existence of naturally distinct bacterial species and genetic approaches to distinguish them. Bacterial genomes in public databases form distinct groups, but these databases are subject to isolation and deposition biases. We compared 5,203 bacterial genomes from 1,457 environmental metagenomic samples to test for distinct clouds of diversity, and evaluated metrics that could be...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: be068873-c33d-51b9-892f-487fc8edd57f
DOI: 10.1101/647511

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Consistent metagenome-derived metrics verify and define bacterial species boundariesDOI 10.1101/647511Read

An ANI gap within bacterial species that advances the definitions of intra-species unitsSemantic proximity Read

Genomic insights that advance the species definition for prokaryotes.Semantic proximity Read

Recombination and the Species Structure of the Genus <i>Bacteroides</i>Semantic proximity Read

Unbinned contigs expand known diversity in the global microbiome.Semantic proximity Read

An integrated metagenomics pipeline for strain profiling reveals novel patterns of bacterial transmission and biogeography.Semantic proximity Read

ANI-based species boundaries and functional divergence in the core proteome of human-associated BifidobacteriaSemantic proximity Read

16SpeB: Towards defining bacterial species boundaries by intra-species gene sequence identitySemantic proximity Read

Towards a balanced view of the bacterial tree of life.Semantic proximity Read

The bacterial species challenge: making sense of genetic and ecological diversity.Semantic proximity Read

An integrated metagenomics pipeline for strain profiling reveals novel patterns of transmission and global biogeography of bacteriaSemantic proximity Read

Comparative performance of reference-based metagenomic tools to identify species-level taxa among families of bacteria: benchmarking <i>Mycobacteriaceae</i> and <i>Neisseriaceae</i>Semantic proximity Read

Metagenome-assembled genomes from a population-based cohort uncover novel gut species and within-species diversity, revealing prevalent disease associations.Semantic proximity Read