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Article

Histone modification signature at myeloperoxidase and proteinase 3 in patients with anti-neutrophil cytoplasmic autoantibody-associated vasculitis

12 Aug 2016

Abstract excerpt

Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a systemic autoimmune disease characterized by destructive vascular inflammation. Two prominent ANCA autoantigens are myeloperoxidase (MPO) and proteinase 3 (PR3), and transcription of MPO and PRTN3, the genes encoding the autoantigens, is associated with disease activity. We investigated whether patients with AAV have alterations in...

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Share to Inflammasome and immune disorders
Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms
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PMID: 27752292
DOI: 10.1186/s13148-016-0251-0

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