Article
Identification of aberrant luminal progenitors and mTORC1 as a potential breast cancer prevention target in BRCA2 mutation carriers.
Nature cell biology - 1 Jan 2024
Joyce Rachel, Pascual Rosa, Heitink Luuk, Capaldo Bianca D, Vaillant François, Christie Michael, Tsai Minhsuang, Surgenor Elliot, Anttila Casey J A, Rajasekhar Pradeep, Jackling Felicity C, Trussart Marie, Milevskiy Michael J G, Song Xiaoyu, Li Mengbo, Teh Charis E, Gray Daniel H D, Smyth Gordon K, Chen Yunshun, Lindeman Geoffrey J, Visvader Jane E
Abstract excerpt
Inheritance of a BRCA2 pathogenic variant conveys a substantial life-time risk of breast cancer. Identification of the cell(s)-of-origin of BRCA2-mutant breast cancer and targetable perturbations that contribute to transformation remains an unmet need for these individuals who frequently undergo prophylactic mastectomy. Using preneoplastic specimens from age-matched, premenopausal females, here we show broad...
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