Article

Evidence for S <sub>331</sub> -G-S-L within the amyloid core of myocilin olfactomedin domain fibrils based on low-resolution 3D solid-state NMR spectra

2024-08-09

Abstract excerpt

<h4>ABSTRACT</h4> Myocilin-associated glaucoma is a protein-conformational disorder associated with formation of a toxic amyloid-like aggregate. Numerous destabilizing single point variants, distributed across the myocilin olfactomedin β-propeller (OLF, myocilin residues 245-504, 30 kDa) are associated with accelerated disease progression. In vitro , wild type (WT) OLF can be promoted to form thioflavin T (ThT)-...

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Literature Corpus work: bd99fc80-097d-5713-9769-23c52a6a0263
DOI: 10.1101/2024.08.09.606901

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