Article

The Antineoplastic Role of STAT5 Inhibition in BCRABL1-Positive Cells Exposed to Pimozide Alone and in Combination with Dasatinib and Ponatinib

2021-10-11

Abstract excerpt

<h4>Background: </h4> Though tyrosine kinase inhibitors managed to reach outstanding responses in the treatment of Chronic Myeloid Leukemia, resistance is still a challenging point, occurring in approximately 10–20% of the cases, due to several mechanisms. STAT5 expression has been strictly linked to resistance and disease progression and may thus represent a significant target to overcome resistance to TKI...

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Literature Corpus work: bd947060-7c8a-5005-b173-97dab5febd0a
DOI: 10.20944/preprints202110.0171.v1

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