Article

Epitope Engineered Human Haematopoietic Stem Cells are Shielded from CD123-targeted Immunotherapy

2023-07-12

Abstract excerpt

<h4>Summary</h4> Targeted eradication of transformed or otherwise dysregulated cells using monoclonal antibodies (mAb), antibody-drug conjugates (ADC), T cell engagers (TCE) or chimeric antigen receptor (CAR) cells is very effective for haematologic diseases. Unlike the breakthrough progress achieved for B cell malignancies, there is a pressing need to find suitable antigens for immunotherapy of myeloid malignanc...

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Literature Corpus work: bd7db515-9013-5d34-a1b3-7e75eb9ccdb3
DOI: 10.1101/2023.07.11.547391

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