Article
CD33-CD123 IF-THEN Gating Reduces Toxicity while Enhancing the Specificity and Memory Phenotype of AML-Targeting CAR-T Cells.
Blood cancer discovery - 8 Jan 2025
Jambon Samy, Sun Jianping, Barman Shawn, Muthugounder Sakunthala, Bito Xue Rachel, Shadfar Armita, Kovach Alexandra E, Wood Brent L, Thoppey Manoharan Varsha, Morrissy A Sorana, Bhojwani Deepa, Wayne Alan S, Pulsipher Michael A, Kim Yong-Mi, Asgharzadeh Shahab, Parekh Chintan, Moghimi Babak
Abstract excerpt
SIGNIFICANCE: Our study demonstrates the use of "IF-THEN" SynNotch-gated CAR-T cells targeting CD33 and CD123 in AML reduces off-tumor toxicity. This strategy enhances T-cell phenotype, improves expansion, preserves HSPCs, and mitigates cytokine release syndrome-addressing critical limitations of existing AML CAR-T therapies.
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