Back to search

Article

Novel mechanisms of efflux-mediated levofloxacin resistance and reduced amikacin susceptibility in <i>Stenotrophomonas maltophilia</i>

2020-07-18

Abstract excerpt

Fluoroquinolone resistance in Stenotrophomonas maltophilia is multi-factorial, but the most significant factor is production of efflux pumps, particularly SmeDEF. Here we report that mutations in the glycosyl transferase gene smlt0622 in S. maltophilia K279a mutant K M6 cause constitutive activation of SmeDEF production, leading to elevated levofloxacin MIC. Selection of a levofloxacin-resistant K M6 derivative...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
bd6187f2-97ca-589f-b95c-ed04719c0aac
DOI
10.1101/2020.07.18.210146
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Novel mechanisms of efflux-mediated levofloxacin resistance and reduced amikacin susceptibility in <i>Stenotrophomonas maltophilia</i>DOI 10.1101/2020.07.18.210146
TonB dependent uptake of β-lactam antibiotics in the opportunistic human pathogen <i>Stenotrophomonas maltophilia</i>Semantic proximity
Mechanisms of antimicrobial resistance in Stenotrophomonas maltophilia: a review of current knowledge.Semantic proximity
Efflux pump systems as key contributors to multidrug resistance in Stenotrophomonas maltophilia: Physiological roles and gene regulationSemantic proximity
The efflux pump SmeDEF contributes to trimethoprim-sulfamethoxazole resistance in Stenotrophomonas maltophilia.Semantic proximity
A TetR-like transcriptional regulator in <i>Stenotrophomonas maltophilia</i> involved in fatty acid metabolism is controlled by quorum sensing signalsSemantic proximity
Comparative genomics analysis of Stenotrophomonas maltophilia strains from a communitySemantic proximity
Emergence of fluoroquinolone resistance and possible mechanisms in clinical isolates of Stenotrophomonas maltophilia from Iran.Semantic proximity
Resistance of Stenotrophomonas maltophilia to Fluoroquinolones: Prevalence in a University Hospital and Possible Mechanisms.Semantic proximity
Whole-genome sequencing identifies emergence of a quinolone resistance mutation in a case of Stenotrophomonas maltophilia bacteremia.Semantic proximity
Overexpression of the multidrug efflux pump SmeDEF impairs Stenotrophomonas maltophilia physiology.Semantic proximity
Clonal transmission and new mechanism of resistance to trimethoprim-sulfamethoxazole in <i>Stenotrophomonas maltophilia</i> strains isolated in a neonatology unit at Antananarivo, Madagascar, deciphered by whole genome sequence analysisSemantic proximity
SmeDEF multidrug efflux pump contributes to intrinsic multidrug resistance in Stenotrophomonas maltophilia.Semantic proximity
Select a neighboring publication to make it the new centre.