Article
Whole-genome sequencing identifies emergence of a quinolone resistance mutation in a case of Stenotrophomonas maltophilia bacteremia.
Antimicrobial agents and chemotherapy - 1 Nov 2015
Pak Theodore R, Altman Deena R, Attie Oliver, Sebra Robert, Hamula Camille L, Lewis Martha, Deikus Gintaras, Newman Leah C, Fang Gang, Hand Jonathan, Patel Gopi, Wallach Fran, Schadt Eric E, Huprikar Shirish, van Bakel Harm, Kasarskis Andrew, Bashir Ali
Abstract excerpt
Whole-genome sequences for Stenotrophomonas maltophilia serial isolates from a bacteremic patient before and after development of levofloxacin resistance were assembled de novo and differed by one single-nucleotide variant in smeT, a repressor for multidrug efflux operon smeDEF. Along with sequenced isolates from five contemporaneous cases, they displayed considerable diversity compared against all published...
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