Article

TonB dependent uptake of β-lactam antibiotics in the opportunistic human pathogen <i>Stenotrophomonas maltophilia</i>

2019-04-22

Abstract excerpt

The β-lactam antibiotic ceftazidime is one of only a handful of drugs with proven clinical efficacy against the opportunistic human pathogen Stenotrophomonas maltophilia , Here, we show that mutations in the energy transducer TonB, encoded by smlt0009 in S. maltophilia , confer ceftazidime resistance. This breaks the dogma that β-lactams enter Gram-negative bacteria only by passive diffusion through outer membr...

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Literature Corpus work: 0c14b90f-42d5-5565-9e50-cc202442dc9f
DOI: 10.1101/615369

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