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WEGS: a cost-effective sequencing method for genetic studies combining high-depth whole exome and low-depth whole genome

2023-05-01

Abstract excerpt

0 Whole genome sequencing (WGS) at high-depth (30X) allows the accurate discovery of variants in the coding and non-coding DNA regions and helps elucidate the genetic underpinnings of human health and diseases. Yet, due to the prohibitive cost of high-depth WGS, most large-scale genetic association studies use genotyping arrays or high-depth whole exome sequencing (WES). Here we propose a novel, cost-effective met...

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Literature Corpus work: bd5c157e-8e8a-5b11-89b4-77ec5a2df8e3
DOI: 10.1101/2023.04.27.538531

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