Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Yield of genetic association signals from genomes, exomes and imputation in the UK Biobank.

Nature genetics - 1 Nov 2024

Gaynor Sheila M, Joseph Tyler, Bai Xiaodong, Zou Yuxin, Boutkov Boris, Maxwell Evan K, Delaneau Olivier, Hofmeister Robin J, Krasheninina Olga, Balasubramanian Suganthi, Marcketta Anthony, Backman Joshua, Reid Jeffrey G, Overton John D, Lotta Luca A, Marchini Jonathan, Salerno William J, Baras Aris, Abecasis Goncalo R, Thornton Timothy A

Abstract excerpt

Whole-genome sequencing (WGS), whole-exome sequencing (WES) and array genotyping with imputation (IMP) are common strategies for assessing genetic variation and its association with medically relevant phenotypes. To date, there has been no systematic empirical assessment of the yield of these approaches when applied to hundreds of thousands of samples to enable the discovery of complex trait genetic signals....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Specimen Banks
Share to Exome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exome Sequencing

Share to Genome, Human

Share to Genome-Wide Association Study

Share to UK Biobank

Share to United Kingdom

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 39322778
DOI: 10.1038/s41588-024-01930-4
PMCID: PMC11549045

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Yield of genetic association signals from genomes, exomes and imputation in the UK Biobank.PMID 39322778Read ↗

Imputation-based assessment of next generation rare exome variant arrays.Semantic proximity Read ↗

Whole-exome imputation within UK Biobank powers rare coding variant association and fine-mapping analyses.Semantic proximity Read ↗

Evaluating the coverage and potential of imputing the exome microarray with next-generation imputation using the 1000 Genomes Project.Semantic proximity Read ↗

Accurate rare variant phasing of whole-genome and whole-exome sequencing data in the UK Biobank.Semantic proximity Read ↗

A cost-effective sequencing method for genetic studies combining high-depth whole exome and low-depth whole genomeSemantic proximity Read ↗

Imputation and polygenic score performance of low coverage whole-genome sequencing and genotyping arrays in diverse human populationsSemantic proximity Read ↗

Boosting the Power of Rare Variant Association Studies by Imputation Using Large-scale Sequencing Population.Semantic proximity Read ↗

Accurate rare variant phasing of whole-genome and whole-exome sequencing data in the UK BiobankSemantic proximity Read ↗

WEGS: a cost-effective sequencing method for genetic studies combining high-depth whole exome and low-depth whole genomeSemantic proximity Read ↗

Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel.Semantic proximity Read ↗

Low coverage whole genome sequencing enables accurate assessment of common variants and calculation of genome-wide polygenic scoresSemantic proximity Read ↗

Sequencing and Imputation in GWAS: Cost-Effective Strategies to Increase Power and Genomic Coverage Across Diverse PopulationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.