Article

Transposable elements shape olaparib response according to BRCA1 status in triple-negative breast cancer

2026-07-16

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Triple-negative breast cancer (TNBC) is an aggressive subtype with limited therapeutic options. While PARP inhibitors, such as olaparib, show promise in BRCA1-deficient TNBC through synthetic lethality, up to 50% of patients fail to respond, highlighting the need to understand the molecular mechanisms underlying PARP inhibitors efficacy. Transposable elements (TEs), particul...

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Literature Corpus work: bc9448b4-1fad-585d-b1c3-8ede54322930
DOI: 10.64898/2026.07.15.738694

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