Article
Self-organized vascularized human liver spheroids: Serum-free culture conditions and use as tissue building blocks
2025-10-26
Abstract excerpt
Engineering vascularized human liver tissue for in vitro models and in vivo applications remains a major challenge. Here, we describe a scalable approach to generate human liver spheroids with self-organized, lumen-containing vascular networks and demonstrate their use as building blocks for fabricating vascularized tissue layers. Spheroids were formed from HepaRG liver cells, human umbilical vein endothelial ce...
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Identifiers and source
- Literature Corpus work
- bc5f62d0-fc2f-5275-8190-b1bd116de4b4
- DOI
- 10.1101/2025.10.25.684548