Article

The mechanical impact of <i>col11a2</i> loss on joints; <i>col11a2</i> mutant zebrafish show changes to joint development and function, which leads to early onset osteoarthritis

2018-04-17

Abstract excerpt

<h4>Abstract (max 200 words)</h4> Collagen is the major structural component of cartilage and mutations in the genes encoding Type XI collagen are associated with severe skeletal dysplasias (Fibrochondrogenesis and Stickler syndrome) and early onset osteoarthritis. The impact of the lack of Type XI collagen on cell behaviour and mechanical performance during skeleton development is unknown. We studied a zebrafish...

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Literature Corpus work: bbf5c08e-fe6f-50da-a606-e1c44657cb6f
DOI: 10.1101/302307

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