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Article

A novel P53/POMC/Gαs/SASH1 autoregulatory feedback loop activates mutated SASH1 to cause pathologic hyperpigmentation.

Journal of cellular and molecular medicine - 1 Apr 2017

Zhou Ding'an, Wei Zhiyun, Kuang Zhongshu, Luo Huangchao, Ma Jiangshu, Zeng Xing, Wang Ke, Liu Beizhong, Gong Fang, Wang Jing, Lei Shanchuan, Wang Dongsheng, Zeng Jiawei, Wang Teng, He Yong, Yuan Yongqiang, Dai Hongying, He Lin, Xing Qinghe

Abstract excerpt

p53-Transcriptional-regulated proteins interact with a large number of other signal transduction pathways in the cell, and a number of positive and negative autoregulatory feedback loops act upon the p53 response. P53 directly controls the POMC/α-MSH productions induced by ultraviolet (UV) and is associated with UV-independent pathological pigmentation. When identifying the causative gene of dyschromatosis...

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Source

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Identifiers

PMID: 27885802
DOI: 10.1111/jcmm.13022
PMCID: PMC5345616

Genes

SASH1
POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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