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Article

SASH1 regulates melanocyte transepithelial migration through a novel Gαs-SASH1-IQGAP1-E-Cadherin dependent pathway.

Cellular signalling - 1 Jun 2013

Zhou Ding'an, Wei Zhiyun, Deng Shanshan, Wang Teng, Zai Meiqing, Wang Honglian, Guo Luo, Zhang Junyu, Zhong Hailei, He Lin, Xing Qinghe

Abstract excerpt

One important function of melanocytes (MCs) is to produce and transfer melanin to neighbouring keratinocytes (KCs) to protect epithelial cells from UV radiation. The mechanisms regulating the specific migration and localisation of the MC lineage remain unknown. We have found three heterozygous mutations that cause amino acid substitutions in the SASH1 gene in individuals with a kind of dyschromatosis. In...

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Source

Identifiers

PMID: 23333244
DOI: 10.1016/j.cellsig.2012.12.025

Genes

SASH1
IQGAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SASH1 regulates melanocyte transepithelial migration through a novel Gαs-SASH1-IQGAP1-E-Cadherin dependent pathway.PMID 23333244Read ↗

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