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Article

p53 regulates ERK1/2/CREB cascade via a novel SASH1/MAP2K2 crosstalk to induce hyperpigmentation.

Journal of cellular and molecular medicine - 1 Oct 2017

Zhou Ding'an, Kuang Zhongshu, Zeng Xing, Wang Ke, Ma Jiangshu, Luo Huangchao, Chen Mei, Li Yan, Zeng Jiawei, Li Shu, Luan Fujun, He Yong, Dai Hongying, Liu Beizhong, Li Hui, He Lin, Xing Qinghe

Abstract excerpt

We previously reported that three point mutations in SASH1 and mutated SASH1 promote melanocyte migration in dyschromatosis universalis hereditaria (DUH) and a novel p53/POMC/Gαs/SASH1 autoregulatory positive feedback loop is regulated by SASH1 mutations to induce pathological hyperpigmentation phenotype. However, the underlying mechanism of molecular regulation to cause this hyperpigmentation disorder still...

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Share to RNA Interference
Share to Cyclic AMP Response Element-Binding Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Signal-Regulated MAP Kinases

Share to Hyperpigmentation

Share to MAP Kinase Kinase 2

Share to Pigmentation Disorders

Share to Skin Diseases, Genetic

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 28382689
DOI: 10.1111/jcmm.13168
PMCID: PMC5618682

Genes

SASH1
POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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