Article

Targeting the paralog protein for degradation accounts for the opposite roles of NRBP1 and NRBP2 in regulating LINE1 retrotransposition

2024-06-15

Abstract excerpt

<h4>Summary</h4> Gene duplication generates paralogs undergoing diverse fates during evolution and serves as a potent catalyst of biological complexity. Paralogs frequently share redundant functions and may also exhibit antagonistic activities by competing for common interaction partners. Here we show that the gene paralogs NRBP1 and NRBP2 oppositely regulate LINE1 retrotransposition, via influencing integrity...

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Literature Corpus work: bbcf88d4-32e2-5137-8088-45d68feba330
DOI: 10.1101/2024.06.14.598964

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