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The ancient function of RB-E2F Pathway: insights from its evolutionary history

20 Sept 2010

Abstract excerpt

BACKGROUND: The RB-E2F pathway is conserved in most eukaryotic lineages, including animals and plants. E2F and RB family proteins perform crucial functions in cycle controlling, differentiation, development and apoptosis. However, there are two kinds of E2Fs (repressive E2Fs and active E2Fs) and three RB family members in human. Till now, the detail evolutionary history of these protein families and how RB-E2F...

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PMID: 20849664
DOI: 10.1186/1745-6150-5-55

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