Article

Age pigment lipofuscin causes oxidative stress, lysosomal dysfunction, and pyroptotic cell death

2024-03-28

Abstract excerpt

<h4>ABSTRACT</h4> Accumulation of the age pigment lipofuscin represents a ubiquitous hallmark of the aging process. However, our knowledge about cellular effects of lipofuscin accumulation is potentially flawed, because previous research mainly utilized highly artificial methods of lipofuscin generation. In order to address this tremendous problem, we developed a convenient protocol for isolation of authentic lip...

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Literature Corpus work: bb602c15-2097-5052-a2a5-bb212c096211
DOI: 10.1101/2024.03.25.586520

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