Article
Production and characterization of monoclonal antibodies against major histocompatibility complex class I chain-related gene A.
Tissue antigens - 1 Nov 2008
Wongsena W, Sconocchia G, Cho H S, Chang C-C, Wang X, Klumkrathok K, Ferrone S, Leelayuwat C
Abstract excerpt
Major histocompatibility complex (MHC) class I chain-related gene A (MICA), a ligand for the activating immunoreceptor natural killer group 2D (NKG2D), is expressed on stressed cells such as tumor cells. Study of expression of this molecule on tumor cells and patients' sera is useful to define patients' stages leading to proper selection of therapy. In this study, mouse anti-MICA monoclonal antibodies (mAbs) were...
Topics
- Alleles
- Animals
- Antibodies, Monoclonal
- Biolistics
- Cell Line, Tumor
- Cloning, Molecular
- Female
- Genes, MHC Class I
- HeLa Cells
- Histocompatibility Antigens Class I
- Humans
- Mice
- Mice, Inbred BALB C