Palm oil-containing high-fat diet with LPS and CCl4 C57BL/6J mouse model induces the progression of NASH/liver fibrosis and remodels the gut microbiota and its function

Abstract excerpt

<title>Abstract</title> <p>Animal models of non-alcoholic steatohepatitis (NASH) and liver fibrosis are essential for preclinical research of novel drugs. A high-fat diet (HFD) animal model has an indispensable role in the research of gut-liver axis by generating an imbalance of gut microbiota and intestinal leakage, resulting in translocation of harmful bacterial metabolites and lipopolysaccharides (LPSs) to the...

Topics

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• Diet and metabolism studies
• Diet, Metabolism, and Disease
• Gut microbiota and health
• Liver Disease Diagnosis and Treatment

Identifiers and source

Literature Corpus work

445f5264-7a91-50c4-88d8-42d6b18363e1

DOI

10.21203/rs.3.rs-1714461/v1