Article

Gut Microbiota Protects Against Liver Injury and Fibrosis via Activation of the CYP Eicosanoid Pathway

2025-04-03

Abstract excerpt

<title>Abstract</title> <p>Gut microbiota has been shown to play an important role in the pathogenesis of liver injury and fibrosis, but the specific microbial factors or pathways involved remain poorly defined. Here we show that specific gut microbial metabolites, notably indole, activate the cytochrome P450 (CYP) eicosanoid pathway in the liver and protect the liver against liver injury and fibrosis. Using LC-M...

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Literature Corpus work: 9348b939-ee1f-58c1-9bf8-4e3a7278fc0d
DOI: 10.21203/rs.3.rs-6356145/v1

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