Article

Molecular dynamics of the interaction between the ALS/FTD-associated (GGGGCC)n RNA G-quadruplex structure and the three RRM domains of hnRNP H

2023-05-24

Abstract excerpt

<h4>ABSTRACT</h4> Hexanucleotide repeat expansions (HRE), located in the first intron of chromosome 9 open reading frame 72 (C9orf72) are the most common genetic abnormality associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Presence of the HRE may cause various effects to neuronal cells, leading to pathogenicity. One of these is the sequestration of RNA-binding proteins by thr...

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Literature Corpus work: ba91acfb-f846-573e-a3cb-af57f0713134
DOI: 10.1101/2023.05.24.541672

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